Mus musculus Protein: Nudt1 | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-259420.6 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | Nudt1 | ||||||||||||||
Protein Name | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | ||||||||||||||
Synonyms | Mth1; | ||||||||||||||
Species | Mus musculus | ||||||||||||||
Ensembl Protein | ENSMUSP00000106451 | ||||||||||||||
InnateDB Gene | IDBG-206856 (Nudt1) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. {ECO:0000269PubMed:7592783}. | ||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus. Nucleus membrane. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | High expression levels detected in thymus, liver, spleen, kidney, testis and large intestine, with lower levels detected in brain, heart, lung and stomach (at protein level). Expressed in kidney, liver and small intestine. {ECO:0000269PubMed:7592783}. | ||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | MGI:109280 | ||||||||||||||
InterPro |
IPR000086
NUDIX hydrolase domain IPR003563 7,8-dihydro-8-oxoguanine triphosphatase IPR015797 NUDIX hydrolase domain-like IPR020476 NUDIX hydrolase |
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PFAM |
PF00293
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PRINTS |
PR01403
PR00502 |
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PIRSF | |||||||||||||||
SMART | |||||||||||||||
TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | P53368 | ||||||||||||||
PhosphoSite | PhosphoSite-P53368 | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 17766 | ||||||||||||||
UniGene | Mm.118846 | ||||||||||||||
RefSeq | XP_006504718 | ||||||||||||||
MGI ID | |||||||||||||||
MGI Symbol | Nudt1 | ||||||||||||||
OMIM | |||||||||||||||
CCDS | CCDS19818 | ||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | AK011695 AK088309 AK168312 BC021940 BC098239 CH466529 D49956 D88356 | ||||||||||||||
GenPept | AAH21940 AAH98239 BAA08711 BAA19866 BAB27785 BAC40274 BAE40252 EDL19122 EDL19123 | ||||||||||||||