InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppp1r14d

Summary

InnateDB Protein

IDBP-259439.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppp1r14d

Protein Name

protein phosphatase 1, regulatory (inhibitor) subunit 14D

Synonyms

2010107K19Rik; GBPI-1; Ppp1r14;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106444

InnateDB Gene

IDBG-199107 (Ppp1r14d)

Protein Structure

UniProt Annotation

Function

Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Isoform 1 is detected in intestine, kidney, lung, spleen, stomach and brain. Isoform 2 is detected in testis. {ECO:0000269PubMed:12974676}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity

Biological Process

GO:0035304	regulation of protein dephosphorylation
GO:0042325	regulation of phosphorylation
GO:0043086	negative regulation of catalytic activity

Cellular Component

GO:0005575	cellular_component
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1919362

InterPro

IPR008025 PKC-activated phosphatase-1 inhibitor

PFAM

PF05361

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TT52

PhosphoSite

PhosphoSite-Q7TT52

TrEMBL

UniProt Splice Variant

Entrez Gene

72112

UniGene

RefSeq

NP_001277725

MGI ID

MGI Symbol

Ppp1r14d

OMIM

CCDS

CCDS71118

HPRD

IMGT

EMBL

AF408400 AK008348 AL929318 AY179331 BC024547

GenPept

AAH24547 AAK97532 AAO47399 BAB25620 CAM25336