InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FZD1

Summary

InnateDB Protein

IDBP-25944.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZD1

Protein Name

frizzled family receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000287934

InnateDB Gene

IDBG-25942 (FZD1)

Protein Structure

UniProt Annotation

Function

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Subcellular Localization

Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	7 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0017147	Wnt-protein binding
GO:0030165	PDZ domain binding
GO:0042813	Wnt-activated receptor activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001944	vasculature development
GO:0003149	membranous septum morphogenesis
GO:0003150	muscular septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0007166	cell surface receptor signaling pathway
GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway
GO:0007267	cell-cell signaling
GO:0007409	axonogenesis
GO:0007420	brain development
GO:0008406	gonad development
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030514	negative regulation of BMP signaling pathway
GO:0030855	epithelial cell differentiation
GO:0035414	negative regulation of catenin import into nucleus
GO:0035425	autocrine signaling
GO:0042493	response to drug
GO:0044338	canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
GO:0044339	canonical Wnt receptor signaling pathway involved in osteoblast differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048286	lung alveolus development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060022	hard palate development
GO:0060070	canonical Wnt signaling pathway
GO:0060412	ventricular septum morphogenesis
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090179	planar cell polarity pathway involved in neural tube closure

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032589	neuron projection membrane
GO:0045177	apical part of cell