InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tyro3

Summary

InnateDB Protein

IDBP-259508.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tyro3

Protein Name

TYRO3 protein tyrosine kinase 3

Synonyms

AI323366; Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif; TK19-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106410

InnateDB Gene

IDBG-199993 (Tyro3)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269PubMed:15650770, ECO:0000269PubMed:20363878, ECO:0000269PubMed:21084607, ECO:0000269PubMed:21291561}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Abundant in the brain and lower levels in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001779	natural killer cell differentiation
GO:0006468	protein phosphorylation
GO:0007283	spermatogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021885	forebrain cell migration
GO:0030168	platelet activation
GO:0032940	secretion by cell
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042698	ovulation cycle
GO:0043277	apoptotic cell clearance
GO:0043491	protein kinase B signaling
GO:0043524	negative regulation of neuron apoptotic process
GO:0045824	negative regulation of innate immune response
GO:0046777	protein autophosphorylation
GO:0050728	negative regulation of inflammatory response
GO:0051250	negative regulation of lymphocyte activation
GO:0060068	vagina development
GO:0070050	neuron cellular homeostasis
GO:0070527	platelet aggregation

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:104294

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM