Version 5.4
Mus musculus Protein: Grid2ip
Summary
InnateDB Protein IDBP-259636.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grid2ip
Protein Name glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106361
InnateDB Gene IDBG-207711 (Grid2ip)
Protein Structure
UniProt Annotation
Function Postsynaptic scaffolding protein at the Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
Subcellular Localization Isoform 2: Cell junction, synapse, postsynaptic cell membrane. Cell projection, dendritic spine. Note=Localized to the postsynaptic junction site of the parallel fiber-Purkinje cell synapse. Highly present in the dendritic spines.Isoform 3: Cell junction, synapse. Cell projection, dendritic spine. Cell membrane {ECO:0000305}; Lipid- anchor {ECO:0000305}. Note=Localized at the dendritic spines, but also in dendritic shafts apart fron spines.
Disease Associations
Tissue Specificity Isoform 1 is expressed in the cerebellum, but not in the cerebral cortex. Isoform 2 is expressed in the cell body of purkinge cells of the cerebellum and weakly expressed in the cerebrum and the brainstem as well as various nuclei of the thalamus. Isoform 2 is highly expressed in the cerebral cortex than in the cerebellum. Isoform 3 is expressed in the cerebellum and cerebrum. {ECO:0000269PubMed:11826110, ECO:0000269PubMed:16835239}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0030036 actin cytoskeleton organization
GO:0060292 long term synaptic depression
Cellular Component
GO:0030054 cell junction
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:2176213
InterPro IPR001478 PDZ domain
IPR015425 Formin, FH2 domain
PFAM PF00595
PF13180
PF02181
PRINTS
PIRSF
SMART SM00228
SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0QWG9
PhosphoSite PhosphoSite-Q0QWG9
TrEMBL
UniProt Splice Variant
Entrez Gene 170935
UniGene Mm.197460
RefSeq NP_001152793
MGI ID
MGI Symbol Grid2ip
OMIM
CCDS CCDS51689
HPRD
IMGT
EMBL AF099933 AY377834 AY377835 BC075624 DQ193535
GenPept AAG31020 AAH75624 ABB04525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca