InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eapp

Summary

InnateDB Protein

IDBP-259678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eapp

Protein Name

E2F-associated phosphoprotein

Synonyms

1810011O16Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106341

InnateDB Gene

IDBG-139557 (Eapp)

Protein Structure

UniProt Annotation

Function

May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0008284	positive regulation of cell proliferation
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

MGI:1913516

InterPro

IPR019370 E2F-associated phosphoprotein

PFAM

PF10238

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5BU09

PhosphoSite

PhosphoSite-Q5BU09

TrEMBL

UniProt Splice Variant

Entrez Gene

66266

UniGene

Mm.416371

RefSeq

MGI ID

MGI Symbol

Eapp

OMIM

CCDS

HPRD

IMGT

EMBL

AK007442 AK012800 AY882557 BC037622

GenPept

AAH37622 AAX20161 BAB25042 BAB28479