InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ralgapa1

Summary

InnateDB Protein

IDBP-259726.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ralgapa1

Protein Name

Ral GTPase activating protein, alpha subunit 1

Synonyms

2310003F20Rik; 4930400K19Rik; AI563624; Garnl1; GRIPE; mKIAA0884; Tulip1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106315

InnateDB Gene

IDBG-140803 (Ralgapa1)

Protein Structure

UniProt Annotation

Function

Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). May interact with the HLH region of TCF3/isoform E12. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12200424}. Nucleus {ECO:0000269PubMed:12200424}. Note=Translocated to the nucleus, when associated with TCF3/E12.

Disease Associations

Tissue Specificity

Expressed during embryogenesis. Expressed in the adult brain, particularly in neurons of the cortex and hippocampus. {ECO:0000269PubMed:12200424}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005488	binding
GO:0017123	Ral GTPase activator activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0032859	activation of Ral GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction