InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Skp2

Summary

InnateDB Protein

IDBP-259952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Skp2

Protein Name

S-phase kinase-associated protein 2 (p45)

Synonyms

4930500A04Rik; FBXL1; FWD1; p45;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106215

InnateDB Gene

IDBG-128953 (Skp2)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of the SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. The SCF complex provides substrate specificity and interacts with both, the E2 ubiquitin-conjugating enzyme and the substrate. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	114 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000209	protein polyubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051726	regulation of cell cycle
GO:0071460	cellular response to cell-matrix adhesion

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0019005	SCF ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1351663

InterPro

IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype

PFAM

PF00646
PF12937
PF13013

PRINTS

PIRSF

SMART

SM00256
SM00367

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z0Z3

PhosphoSite

PhosphoSite-Q9Z0Z3

TrEMBL

UniProt Splice Variant

Entrez Gene

27401

UniGene

Mm.413351

RefSeq

NP_663443

MGI ID

MGI Symbol

Skp2

OMIM

CCDS

HPRD

IMGT

EMBL

AF083215 AK032979 AK037002 AK044212 BC003468

GenPept

AAD16037 AAH03468 BAC28108 BAC31819