InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lyst

Summary

InnateDB Protein

IDBP-259990.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Lyst

Protein Name

lysosomal trafficking regulator

Synonyms

beige; bg; D13Sfk13;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106188

InnateDB Gene

IDBG-130720 (Lyst)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0002446	neutrophil mediated immunity
GO:0002456	T cell mediated immunity
GO:0006644	phospholipid metabolic process
GO:0007017	microtubule-based process
GO:0007040	lysosome organization
GO:0007596	blood coagulation
GO:0030595	leukocyte chemotaxis
GO:0032438	melanosome organization
GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway
GO:0032816	positive regulation of natural killer cell activation
GO:0033299	secretion of lysosomal enzymes
GO:0033364	mast cell secretory granule organization
GO:0042267	natural killer cell mediated cytotoxicity
GO:0042493	response to drug
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0043473	pigmentation
GO:0048753	pigment granule organization
GO:0051607	defense response to virus
GO:0055091	phospholipid homeostasis

Cellular Component

GO:0005829	cytosol
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:107448

InterPro

IPR000409 BEACH domain
IPR001680 WD40 repeat
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR016024 Armadillo-type fold
IPR017986 WD40-repeat-containing domain

PFAM

PF02138
PF00400

PRINTS

PIRSF

SMART

SM01026
SM00320

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite