InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sord

Summary

InnateDB Protein

IDBP-260044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sord

Protein Name

sorbitol dehydrogenase

Synonyms

Sdh-1; Sdh1; Sodh-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106180

InnateDB Gene

IDBG-202809 (Sord)

Protein Structure

UniProt Annotation

Function

Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. {ECO:0000269PubMed:18799757}.

Subcellular Localization

Mitochondrion membrane {ECO:0000269PubMed:18799757}; Peripheral membrane protein {ECO:0000269PubMed:18799757}. Cell projection, cilium, flagellum {ECO:0000269PubMed:18799757}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.

Disease Associations

Tissue Specificity

Testis has the highest level of expression, followed by kidney, liver, and lung. Low levels of expression are also observed in lens, brain, and skeletal muscle. Expressed in sperm flagellum and very low expression in the sperm head. {ECO:0000269PubMed:18799757, ECO:0000269PubMed:7601136}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003939	L-iditol 2-dehydrogenase activity
GO:0008270	zinc ion binding
GO:0016491	oxidoreductase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0051287	NAD binding

Biological Process

GO:0006060	sorbitol metabolic process
GO:0006062	sorbitol catabolic process
GO:0030317	sperm motility
GO:0046370	fructose biosynthetic process
GO:0051160	L-xylitol catabolic process
GO:0051164	L-xylitol metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0031514	motile cilium
GO:0031966	mitochondrial membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:98266

InterPro

IPR011032 GroES (chaperonin 10)-like
IPR013149 Alcohol dehydrogenase, C-terminal
IPR013154 Alcohol dehydrogenase GroES-like
IPR020843 Polyketide synthase, enoylreductase

PFAM

PF00107
PF08240

PRINTS

PIRSF

SMART

SM00829

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64442