InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trim9

Summary

InnateDB Protein

IDBP-260095.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trim9

Protein Name

tripartite motif-containing 9

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106149

InnateDB Gene

IDBG-145901 (Trim9)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:20085810}. Cell projection, dendrite {ECO:0000269PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle- associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain. Expression is higher in the cerebral cortex and hippocampus (at protein level). Its expression is mainly confined to the central nervous system. The developing neocortex, the dorsal thalamus, the midbrain, the basal area of the hindbrain and spinal cord show high level of expression during embryogenesis. In adult brain, it is detected in the Purkinje cells of the cerebellum, in the hippocampus, and in the cortex. {ECO:0000269PubMed:11960705, ECO:0000269PubMed:20085810}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:2137354

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003649 B-box, C-terminal
IPR003877 SPla/RYanodine receptor SPRY
IPR003961 Fibronectin, type III
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR011011 Zinc finger, FYVE/PHD-type
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM