InnateDB Protein
|
IDBP-260141.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Sub1
|
Protein Name
|
SUB1 homolog (S. cerevisiae)
|
Synonyms
|
AI842364; P15; P9; Pc4; Rpo2tc1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000106130
|
InnateDB Gene
|
IDBG-129736 (Sub1)
|
Protein Structure
|
|
Function |
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
|
Subcellular Localization |
Nucleus.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
|
Protein-Protein |
5
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
29 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0001205
|
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0003677
|
DNA binding
|
GO:0003697
|
single-stranded DNA binding
|
GO:0003713
|
transcription coactivator activity
|
|
Biological Process |
GO:0006351
|
transcription, DNA-templated
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
|
Cellular Component |
|
PDB ID |
MGI:104811
|
InterPro |
IPR003173
Transcriptional coactivator p15 (PC4)
IPR009044
ssDNA-binding transcriptional regulator
|
PFAM |
PF02229
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P11031
|
PhosphoSite |
PhosphoSite-P11031
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
20024
|
UniGene |
Mm.41746
|
RefSeq |
|
MGI ID |
|
MGI Symbol |
Sub1
|
OMIM |
|
CCDS |
CCDS27387
|
HPRD |
|
IMGT |
|
EMBL |
AK048371
AK049260
AK132021
AK146335
AK151734
AK154114
BC010967
J03750
|
GenPept |
AAA37317
AAH10967
BAC33314
BAC33642
BAE20946
BAE27090
BAE30649
BAE32384
|
|
|