InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myef2

Summary

InnateDB Protein

IDBP-260149.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myef2

Protein Name

myelin basic protein expression factor 2, repressor

Synonyms

9430071B01; mKIAA1341;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106127

InnateDB Gene

IDBG-203410 (Myef2)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA. {ECO:0000269PubMed:7534248, ECO:0000269PubMed:7539003, ECO:0000269PubMed:9282330}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in the brain. {ECO:0000269PubMed:7539003}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003723	RNA binding