InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hif1a

Summary

InnateDB Protein

IDBP-260221.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hif1a

Protein Name

hypoxia inducible factor 1, alpha subunit

Synonyms

AA959795; bHLHe78; HIF1alpha; MOP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106091

InnateDB Gene

IDBG-148620 (Hif1a)

Protein Structure

UniProt Annotation

Function

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15225651}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:15225651}. Note=Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 135 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	33 [view]
Protein-DNA	13 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	135 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding
GO:0035035	histone acetyltransferase binding
GO:0042826	histone deacetylase binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity
GO:0051879	Hsp90 protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001568	blood vessel development
GO:0001666	response to hypoxia
GO:0001755	neural crest cell migration
GO:0001837	epithelial to mesenchymal transition
GO:0001892	embryonic placenta development
GO:0001922	B-1 B cell homeostasis
GO:0001944	vasculature development
GO:0001947	heart looping
GO:0002052	positive regulation of neuroblast proliferation
GO:0002248	connective tissue replacement involved in inflammatory response wound healing
GO:0003151	outflow tract morphogenesis
GO:0003208	cardiac ventricle morphogenesis
GO:0006089	lactate metabolic process
GO:0006110	regulation of glycolytic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006879	cellular iron ion homeostasis
GO:0007165	signal transduction
GO:0007595	lactation
GO:0008542	visual learning
GO:0010573	vascular endothelial growth factor production
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010634	positive regulation of epithelial cell migration
GO:0010870	positive regulation of receptor biosynthetic process
GO:0014850	response to muscle activity
GO:0019896	axon transport of mitochondrion
GO:0021502	neural fold elevation formation
GO:0021987	cerebral cortex development
GO:0030154	cell differentiation
GO:0030502	negative regulation of bone mineralization
GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007	negative regulation of TOR signaling
GO:0032364	oxygen homeostasis
GO:0032909	regulation of transforming growth factor beta2 production
GO:0032963	collagen metabolic process
GO:0035162	embryonic hemopoiesis
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042127	regulation of cell proliferation
GO:0042541	hemoglobin biosynthetic process
GO:0042593	glucose homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045087	innate immune response (InnateDB)
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045926	negative regulation of growth
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046716	muscle cell cellular homeostasis
GO:0046886	positive regulation of hormone biosynthetic process
GO:0048514	blood vessel morphogenesis
GO:0048546	digestive tract morphogenesis
GO:0050790	regulation of catalytic activity
GO:0051216	cartilage development
GO:0051541	elastin metabolic process
GO:0060574	intestinal epithelial cell maturation
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development
GO:0061298	retina vasculature development in camera-type eye
GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070243	regulation of thymocyte apoptotic process
GO:0070244	negative regulation of thymocyte apoptotic process
GO:0071347	cellular response to interleukin-1
GO:0071456	cellular response to hypoxia
GO:0071542	dopaminergic neuron differentiation
GO:2001054	negative regulation of mesenchymal cell apoptotic process