Version 5.4
Mus musculus Protein: Cmah
Summary
InnateDB Protein IDBP-260371.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cmah
Protein Name cytidine monophospho-N-acetylneuraminic acid hydroxylase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000106021
InnateDB Gene IDBG-138610 (Cmah)
Protein Structure
UniProt Annotation
Function Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N- glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells, except in brain. {ECO:0000269PubMed:22692205}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:7608218, ECO:0000269PubMed:8781965}.Isoform 2: Endoplasmic reticulum {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in all tissues tested, except in brain. {ECO:0000269PubMed:7608218}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
GO:0030338 CMP-N-acetylneuraminate monooxygenase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006054 N-acetylneuraminate metabolic process
GO:0046381 CMP-N-acetylneuraminate metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
Protein Structure and Domains
PDB ID MGI:103227
InterPro IPR001279 Beta-lactamase-like
IPR017941 Rieske [2Fe-2S] iron-sulphur domain
PFAM PF00753
PF00355
PRINTS
PIRSF
SMART SM00849
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61419
PhosphoSite PhosphoSite-Q61419
TrEMBL
UniProt Splice Variant
Entrez Gene 12763
UniGene Mm.8396
RefSeq NP_031743
MGI ID
MGI Symbol Cmah
OMIM
CCDS CCDS26376
HPRD
IMGT
EMBL AB061276 AB061277 AB061346 AL589744 BC055079 D21826
GenPept AAH55079 BAA04850 BAB91361 BAB91362 BAB91553 CAI26039

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca