InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ywhaz

Summary

InnateDB Protein

IDBP-260435.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ywhaz

Protein Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

Synonyms

1110013I11Rik; 14-3-3zeta; AI596267; AL022924; AU020854;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105991

InnateDB Gene

IDBG-135418 (Ywhaz)

Protein Structure

UniProt Annotation

Function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Subcellular Localization

Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 195 experimentally validated interaction(s) in this database.
They are also associated with 557 interaction(s) predicted by orthology.

Experimentally validated
Total	195 [view]
Protein-Protein	195 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	557 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0002553	histamine secretion by mast cell
GO:0006605	protein targeting
GO:0006626	protein targeting to mitochondrion
GO:0010941	regulation of cell death
GO:0042493	response to drug

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0014069	postsynaptic density
GO:0030659	cytoplasmic vesicle membrane
GO:0031252	cell leading edge
GO:0042470	melanosome
GO:0042629	mast cell granule
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome