Version 5.4
Mus musculus Protein: Azin1
Summary
InnateDB Protein IDBP-260502.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Azin1
Protein Name antizyme inhibitor 1
Synonyms 1700085L02Rik; AZI; Oazi; Oazin;
Species Mus musculus
Ensembl Protein ENSMUSP00000105958
InnateDB Gene IDBG-136411 (Azin1)
Protein Structure
UniProt Annotation
Function Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:16916800, PubMed:18062773, PubMed:18508777). Inhibits antizyme-dependent ODC degradation by binding to antizymes (PubMed:18062773). Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1. {ECO:0000269PubMed:10698696, ECO:0000269PubMed:16916800, ECO:0000269PubMed:18062773, ECO:0000269PubMed:18369191, ECO:0000269PubMed:18508777}.
Subcellular Localization Nucleus {ECO:0000269PubMed:19449338}.
Disease Associations
Tissue Specificity Expressed during testis development. {ECO:0000269PubMed:18508777, ECO:0000269PubMed:18973822}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0042978 ornithine decarboxylase activator activity
Biological Process
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0043085 positive regulation of catalytic activity
Cellular Component
Protein Structure and Domains
PDB ID MGI:1859169
InterPro IPR000183 Ornithine/DAP/Arg decarboxylase
IPR002433 Ornithine decarboxylase
IPR009006 Alanine racemase/group IV decarboxylase, C-terminal
IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal
IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal
IPR029066 PLP-binding barrel
PFAM PF00278
PF02784
PRINTS PR01179
PR01182
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35484
PhosphoSite PhosphoSite-O35484
TrEMBL D3Z2P3
UniProt Splice Variant
Entrez Gene 54375
UniGene Mm.490233
RefSeq NP_001095928
MGI ID 3BTN
MGI Symbol Azin1
OMIM
CCDS CCDS37065
HPRD
IMGT
EMBL AC167019 AF032128 AK049680 AK088112 AK088671 BC019412 BC043722
GenPept AAB87464 AAH19412 AAH43722 BAC33870 BAC40151 BAC40494

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca