Version 5.4
Homo sapiens Protein: FBXL12
Summary
InnateDB Protein IDBP-26053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL12
Protein Name F-box and leucine-rich repeat protein 12
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000247977
InnateDB Gene IDBG-26051 (FBXL12)
Protein Structure
UniProt Annotation
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. {ECO:0000269PubMed:23707388}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001810 F-box domain
PFAM PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NXK8
PhosphoSite PhosphoSite-Q9NXK8
TrEMBL K7EPN7
UniProt Splice Variant
Entrez Gene 54850
UniGene Hs.12439
RefSeq NP_060173
HUGO HGNC:13611
OMIM 609079
CCDS CCDS12218
HPRD 12363
IMGT
EMBL AC008752 AK000195 AK027004 AK093760 BC001586 CH471106
GenPept AAH01586 BAA91002 BAB15622 BAG52760 EAW84051

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca