InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Irf4

Summary

InnateDB Protein

IDBP-260549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Irf4

Protein Name

interferon regulatory factor 4

Synonyms

AI385587; IRF-4; LSIRF; Spip;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105936

InnateDB Gene

IDBG-141793 (Irf4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. {ECO:0000269PubMed:22983707, ECO:0000269PubMed:22992523, ECO:0000269PubMed:22992524}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Lymphoid cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	15 [view]
Protein-DNA	54 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0018022	peptidyl-lysine methylation
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042832	defense response to protozoan
GO:0043011	myeloid dendritic cell differentiation
GO:0043388	positive regulation of DNA binding
GO:0043966	histone H3 acetylation
GO:0043967	histone H4 acetylation
GO:0045082	positive regulation of interleukin-10 biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045368	positive regulation of interleukin-13 biosynthetic process
GO:0045404	positive regulation of interleukin-4 biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0072540	T-helper 17 cell lineage commitment