InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clcn3

Summary

InnateDB Protein

IDBP-260555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcn3

Protein Name

chloride channel 3

Synonyms

Clc3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105930

InnateDB Gene

IDBG-156577 (Clcn3)

Protein Structure

UniProt Annotation

Function

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. {ECO:0000269PubMed:15504734, ECO:0000269PubMed:18923035}.

Subcellular Localization

Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Detected in kidney, in the apical part of proximal tubule cells (at protein level). Expressed at high levels in the kidney while a low level expression is seen in the brain. Within the brain, it is prominent in the hippocampus, cerebral cortex and olfactory bulb. {ECO:0000269PubMed:18923035}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030165	PDZ domain binding
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006821	chloride transport
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005769	early endosome
GO:0005770	late endosome
GO:0005794	Golgi apparatus
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030658	transport vesicle membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane