Version 5.4
Mus musculus Protein: Trhr
Summary
InnateDB Protein IDBP-260597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trhr
Protein Name thyrotropin releasing hormone receptor
Synonyms TRH-R1;
Species Mus musculus
Ensembl Protein ENSMUSP00000105918
InnateDB Gene IDBG-138190 (Trhr)
Protein Structure
UniProt Annotation
Function Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004997 thyrotropin-releasing hormone receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:98824
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002120 Thyrotropin-releasing hormone receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)
PFAM PF00001
PF10320
PF10328
PRINTS PR00237
PR00751
PR01654
PR01846
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P21761
PhosphoSite PhosphoSite-P21761
TrEMBL Q32MS1
UniProt Splice Variant
Entrez Gene 22045
UniGene Mm.309350
RefSeq XP_006520810
MGI ID
MGI Symbol Trhr
OMIM
CCDS CCDS37068
HPRD
IMGT
EMBL BC109005 BC109006 BC128269 CH466541 L48936 M59811 M94384
GenPept AAA40437 AAA40480 AAA81559 AAI09006 AAI09007 AAI28270 EDL08750

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca