InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tfap2a

Summary

InnateDB Protein

IDBP-260789.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tfap2a

Protein Name

transcription factor AP-2, alpha

Synonyms

AP-2; Ap-2 (a); Ap2; AP2alpha; Ap2tf; Tcfap2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105822

InnateDB Gene

IDBG-146292 (Tfap2a)

Protein Structure

UniProt Annotation

Function

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269PubMed:15475956}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000982	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000987	core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001822	kidney development
GO:0001843	neural tube closure
GO:0002089	lens morphogenesis in camera-type eye
GO:0003151	outflow tract morphogenesis
GO:0003334	keratinocyte development
GO:0003404	optic vesicle morphogenesis
GO:0003409	optic cup structural organization
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0007423	sensory organ development
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0010172	embryonic body morphogenesis
GO:0010628	positive regulation of gene expression
GO:0010842	retina layer formation
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0014032	neural crest cell development
GO:0021506	anterior neuropore closure
GO:0021559	trigeminal nerve development
GO:0021623	oculomotor nerve formation
GO:0021884	forebrain neuron development
GO:0030335	positive regulation of cell migration
GO:0030501	positive regulation of bone mineralization
GO:0035115	embryonic forelimb morphogenesis
GO:0035136	forelimb morphogenesis
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0043588	skin development
GO:0045595	regulation of cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048485	sympathetic nervous system development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0048730	epidermis morphogenesis
GO:0060021	palate development
GO:0060235	lens induction in camera-type eye
GO:0060325	face morphogenesis
GO:0060349	bone morphogenesis
GO:0061029	eyelid development in camera-type eye
GO:0061303	cornea development in camera-type eye
GO:0070172	positive regulation of tooth mineralization
GO:0071281	cellular response to iron ion
GO:0071711	basement membrane organization
GO:0072210	metanephric nephron development
GO:2000378	negative regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0043231	intracellular membrane-bounded organelle