InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zhx1

Summary

InnateDB Protein

IDBP-260842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zhx1

Protein Name

zinc fingers and homeoboxes 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105797

InnateDB Gene

IDBG-142574 (Zhx1)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co- repressor proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:17056598}. Note=Colocalized in the nucleus with DNMT3B. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain. {ECO:0000269PubMed:8713137}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated