InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf144b

Summary

InnateDB Protein

IDBP-260974.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf144b

Protein Name

ring finger protein 144B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105738

InnateDB Gene

IDBG-149475 (Rnf144b)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006915	apoptotic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:2384986

InterPro

IPR001841 Zinc finger, RING-type
IPR002867 Zinc finger, C6HC-type

PFAM

PF13639
PF14634
PF01485

PRINTS

PIRSF

SMART

SM00184
SM00647

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BKD6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

218215

UniGene

Mm.441168

RefSeq

NP_001164114

MGI ID

MGI Symbol

Rnf144b

OMIM

CCDS

CCDS26491

HPRD

IMGT

EMBL

AK040939 AK052846 AK053529 BC025007

GenPept

AAH25007 BAC30754 BAC35173 BAC35416