InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab3a

Summary

InnateDB Protein

IDBP-261009.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab3a

Protein Name

RAB3A, member RAS oncogene family

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105719

InnateDB Gene

IDBG-164008 (Rab3a)

Protein Structure

UniProt Annotation

Function

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008022	protein C-terminus binding
GO:0051020	GTPase binding
GO:0051117	ATPase binding

Biological Process

GO:0003016	respiratory system process
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007005	mitochondrion organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007274	neuromuscular synaptic transmission
GO:0007409	axonogenesis
GO:0009791	post-embryonic development
GO:0015031	protein transport
GO:0016079	synaptic vesicle exocytosis
GO:0016188	synaptic vesicle maturation
GO:0017157	regulation of exocytosis
GO:0030324	lung development
GO:0031630	regulation of synaptic vesicle fusion to presynaptic membrane
GO:0032781	positive regulation of ATPase activity
GO:0048790	maintenance of presynaptic active zone structure
GO:0050975	sensory perception of touch
GO:0051602	response to electrical stimulus

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0030424	axon
GO:0043195	terminal bouton
GO:0043229	intracellular organelle
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:97843

InterPro

IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt