InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snx5

Summary

InnateDB Protein

IDBP-261134.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snx5

Protein Name

sorting nexin 5

Synonyms

0910001N05Rik; 1810032P22Rik; AU019504; D2Ertd52e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105657

InnateDB Gene

IDBG-208427 (Snx5)

Protein Structure

UniProt Annotation

Function

May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation (By similarity). {ECO:0000250}.

Subcellular Localization

Early endosome membrane {ECO:0000269PubMed:18854019}; Peripheral membrane protein {ECO:0000269PubMed:18854019}; Cytoplasmic side {ECO:0000269PubMed:18854019}. Cell membrane {ECO:0000269PubMed:18854019}; Peripheral membrane protein {ECO:0000269PubMed:18854019}; Cytoplasmic side {ECO:0000269PubMed:18854019}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:18854019}; Peripheral membrane protein {ECO:0000269PubMed:18854019}; Cytoplasmic side {ECO:0000269PubMed:18854019}. Cytoplasm {ECO:0000269PubMed:18854019}. Cell projection, phagocytic cup {ECO:0000269PubMed:18854019}. Cell projection, ruffle {ECO:0000250}. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Targeted to membrane ruffles in response to EGFR stimulation (By similarity). Detected on macropinosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in macrophages (at protein level). {ECO:0000269PubMed:18854019}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006907	pinocytosis

Cellular Component

GO:0001726	ruffle
GO:0001891	phagocytic cup
GO:0005768	endosome
GO:0030659	cytoplasmic vesicle membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0031313	extrinsic component of endosome membrane
GO:0031901	early endosome membrane
GO:0070685	macropinocytic cup