Version 5.4
Homo sapiens Protein: H3F3C
Summary
InnateDB Protein IDBP-26116.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H3F3C
Protein Name H3 histone, family 3C
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000339835
InnateDB Gene IDBG-26114 (H3F3C)
Protein Structure
UniProt Annotation
Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes. {ECO:0000269PubMed:21274551}.
Subcellular Localization Nucleus. Chromosome.
Disease Associations
Tissue Specificity Specifically expressed in the seminiferous tubules of testis. {ECO:0000269PubMed:21274551}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0030307 positive regulation of cell growth
Cellular Component
GO:0000786 nucleosome
GO:0005719 nuclear euchromatin
Protein Structure and Domains
PDB ID
InterPro IPR000164 Histone H3/CENP-A
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00622
PIRSF
SMART SM00428
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NXT2
PhosphoSite PhosphoSite-Q6NXT2
TrEMBL V9H1G0
UniProt Splice Variant
Entrez Gene 440093
UniGene
RefSeq NP_001013721
HUGO HGNC:33164
OMIM
CCDS CCDS31769
HPRD 18443
IMGT
EMBL AC023050 BC066906 HQ873957 V00521
GenPept AAH66906 ADW85800 CAA23780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca