Version 5.4
Mus musculus Protein: Slc24a3
Summary
InnateDB Protein IDBP-261181.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc24a3
Protein Name solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms NCKX3;
Species Mus musculus
Ensembl Protein ENSMUSP00000105634
InnateDB Gene IDBG-208632 (Slc24a3)
Protein Structure
UniProt Annotation
Function Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Abundant in the brain. Highest levels found in selected thalamic nuclei, hippocampal CA1 neurons and in layer IV of the cerebral cortex. Expressed in dental tissues. {ECO:0000269PubMed:22677781}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008273 calcium, potassium:sodium antiporter activity
GO:0015293 symporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2137513
InterPro IPR004481 Sodium/potassium/calcium exchanger
IPR004837 Sodium/calcium exchanger membrane region
PFAM PF01699
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99PD7
PhosphoSite PhosphoSite-Q99PD7
TrEMBL Q8VD29
UniProt Splice Variant
Entrez Gene 94249
UniGene Mm.412872
RefSeq XP_006500515
MGI ID
MGI Symbol Slc24a3
OMIM
CCDS
HPRD
IMGT
EMBL AF314821 AF314822 AL772192 AL808117 AL824715 AL831783 BC005742 BC017615 CH466519
GenPept AAG60049 AAG60050 AAH05742 AAH17615 CAM15824 CAM17347 CAM18366 CAM27508 EDL28479

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca