Version 5.4
Mus musculus Protein: Ralgapa2
Summary
InnateDB Protein IDBP-261224.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ralgapa2
Protein Name Ral GTPase activating protein, alpha subunit 2 (catalytic)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000105613
InnateDB Gene IDBG-208817 (Ralgapa2)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Abundantly expressed in testis, pancreas, lung, thymus, brown fat, and white fat. {ECO:0000269PubMed:16490346}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005488 binding
Biological Process
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:3036245
InterPro IPR000331 Rap GTPase activating protein domain
IPR016024 Armadillo-type fold
PFAM PF02145
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-A3KGS3
TrEMBL B2RX86
UniProt Splice Variant
Entrez Gene 241694
UniGene Mm.489076
RefSeq NP_001028520
MGI ID
MGI Symbol Ralgapa2
OMIM
CCDS CCDS16831
HPRD
IMGT
EMBL BC151040 BC151041
GenPept AAI51041 AAI51042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca