InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANXA3

Summary

InnateDB Protein

IDBP-26124.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA3

Protein Name

annexin A3

Synonyms

ANX3;

Species

Homo sapiens

Ensembl Protein

ENSP00000264908

InnateDB Gene

IDBG-26122 (ANXA3)

Protein Structure

UniProt Annotation

Function

Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0005544	calcium-dependent phospholipid binding
GO:0019834	phospholipase A2 inhibitor activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006909	phagocytosis
GO:0010595	positive regulation of endothelial cell migration
GO:0042742	defense response to bacterium
GO:0043086	negative regulation of catalytic activity
GO:0043312	neutrophil degranulation
GO:0045766	positive regulation of angiogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0042581	specific granule
GO:0070062	extracellular vesicular exosome