InnateDB Protein
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IDBP-261292.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sin3b
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Protein Name
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transcriptional regulator, SIN3B (yeast)
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Synonyms
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2810430C10Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105576
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InnateDB Gene
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IDBG-168505 (Sin3b)
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Protein Structure
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Function |
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. {ECO:0000269PubMed:10620510, ECO:0000269PubMed:7889570}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00810, ECO:0000269PubMed:20170641, ECO:0000269PubMed:7889570}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated |
Total |
29
[view]
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Protein-Protein |
29
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
41 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107158
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InterPro |
IPR003822
Paired amphipathic helix
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PFAM |
PF02671
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q62141
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PhosphoSite |
PhosphoSite-Q62141
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TrEMBL |
Q3TN09
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UniProt Splice Variant |
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Entrez Gene |
20467
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UniGene |
Mm.487812
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RefSeq |
NP_001106719
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MGI ID |
2F05
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MGI Symbol |
Sin3b
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OMIM |
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CCDS |
CCDS52598
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HPRD |
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IMGT |
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EMBL |
AF038848
AK146847
AK165592
AK169433
AK173005
BC020049
BC021160
CH466525
L38622
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GenPept |
AAA69774
AAC04821
AAH20049
AAH21160
BAD32283
BAE27478
BAE38280
BAE41174
EDL10817
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