Version 5.4
Mus musculus Protein: Cst8
Summary
InnateDB Protein IDBP-261314.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cst8
Protein Name cystatin 8 (cystatin-related epididymal spermatogenic)
Synonyms Cres; Cst-rs1;
Species Mus musculus
Ensembl Protein ENSMUSP00000105573
InnateDB Gene IDBG-209122 (Cst8)
Protein Structure
UniProt Annotation
Function Performs a specialized role during sperm development and maturation.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Proximal caput region of the epididymis. Lower expression in the testis. Within the testis it is localized to the elongating spermatids, whereas within the epididymis it is exclusively synthesized by the proximal caput epithelium.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004869 cysteine-type endopeptidase inhibitor activity
Biological Process
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface
Protein Structure and Domains
PDB ID MGI:107161
InterPro IPR000010 Proteinase inhibitor I25, cystatin
PFAM PF00031
PRINTS
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P32766
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 13012
UniGene Mm.467806
RefSeq XP_006498721
MGI ID
MGI Symbol Cst8
OMIM
CCDS CCDS16848
HPRD
IMGT
EMBL AF090691 AF091503 AK018943 AK054409 AK161808 BC049753 S49926
GenPept AAC35390 AAC36316 AAC61754 AAH49753 BAB31489 BAC35768 BAE36585

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca