Version 5.4
Mus musculus Protein: Tmem90b
Summary
InnateDB Protein IDBP-261342.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem90b
Protein Name transmembrane protein 90B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000105560
InnateDB Gene IDBG-209207 (Tmem90b)
Protein Structure
UniProt Annotation
Function May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation. {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:20152115}; Single-pass type II membrane protein {ECO:0000269PubMed:20152115}. Early endosome membrane {ECO:0000269PubMed:20152115}; Single-pass type II membrane protein {ECO:0000269PubMed:20152115}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:20152115}. Cell junction, synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Shuttles between the cell surface and early endosome membrane.
Disease Associations
Tissue Specificity Brain-specific. Expressed in Purkinje neurons in cerebellum. Also detected in the hippocampus. Found at excitatory synapses and postsynaptic cells. {ECO:0000269PubMed:12408845, ECO:0000269PubMed:20152115}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0035254 glutamate receptor binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006886 intracellular protein transport
GO:0009607 response to biotic stimulus
GO:0051965 positive regulation of synapse assembly
GO:0097091 synaptic vesicle clustering
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0014069 postsynaptic density
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0031901 early endosome membrane
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0044297 cell body
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
Protein Structure and Domains
PDB ID MGI:3702158
InterPro IPR007593 CD225/Dispanin family
PFAM PF04505
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2ANU3
PhosphoSite PhosphoSite-AAI47353
TrEMBL B1AYD6
UniProt Splice Variant
Entrez Gene 433485
UniGene Mm.445136
RefSeq
MGI ID
MGI Symbol Syndig1
OMIM
CCDS CCDS38262
HPRD
IMGT
EMBL AL831742 AL845436 BC147352 BC147353 BC147660 BC147661 BX649512 CH466519 CR388226
GenPept AAI47353 AAI47354 AAI47661 AAI47662 CAM13941 CAM20081 EDL28557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca