InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmed9

Summary

InnateDB Protein

IDBP-261397.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmed9

Protein Name

transmembrane emp24 protein transport domain containing 9

Synonyms

2400003B06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105531

InnateDB Gene

IDBG-156412 (Tmed9)

Protein Structure

UniProt Annotation

Function

Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum- Golgi intermediate compartment membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans- Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019905	syntaxin binding

Biological Process

GO:0006810	transport
GO:0007030	Golgi organization
GO:0010638	positive regulation of organelle organization
GO:0015031	protein transport
GO:0048205	COPI coating of Golgi vesicle

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0005794	Golgi apparatus
GO:0016021	integral component of membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0070062	extracellular vesicular exosome