Version 5.4
Mus musculus Protein: Ninl
Summary
InnateDB Protein IDBP-261415.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ninl
Protein Name ninein-like
Synonyms 4930519N13Rik; Gm1004; Gm1634; mKIAA0980;
Species Mus musculus
Ensembl Protein ENSMUSP00000105522
InnateDB Gene IDBG-209428 (Ninl)
Protein Structure
UniProt Annotation
Function Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In interphase cells, NLP is transported to the centrosomes by the dynein-dynactin motor complex. During centrosome maturation, PLK1 directly phosphorylates NLP resulting in its release into the cytoplasm (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005874 microtubule
Protein Structure and Domains
PDB ID MGI:1925427
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZQ12
PhosphoSite PhosphoSite-Q6ZQ12
TrEMBL A2ANB9
UniProt Splice Variant
Entrez Gene 78177
UniGene Mm.398580
RefSeq NP_997087
MGI ID
MGI Symbol Ninl
OMIM
CCDS CCDS50744
HPRD
IMGT
EMBL AK129253 AL808125 BC067071
GenPept AAH67071 BAC98063 CAM17134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca