InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Catsper3

Summary

InnateDB Protein

IDBP-261421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Catsper3

Protein Name

cation channel, sperm associated 3

Synonyms

4921522D01Rik; CACRC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105524

InnateDB Gene

IDBG-156857 (Catsper3)

Protein Structure

UniProt Annotation

Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone. {ECO:0000269PubMed:17227845, ECO:0000269PubMed:17344468}.

Subcellular Localization

Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}; Multi- pass membrane protein {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}. Note=Specifically located in the principal piece of sperm tail.

Disease Associations

Tissue Specificity

Testis-specific. {ECO:0000269PubMed:16107607, ECO:0000269PubMed:17227845}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007275	multicellular organismal development
GO:0030317	sperm motility
GO:0034765	regulation of ion transmembrane transport
GO:0048240	sperm capacitation
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005783	endoplasmic reticulum
GO:0005929	cilium
GO:0016020	membrane
GO:0036128	CatSper complex

Protein Structure and Domains

PDB ID

MGI:1924106

InterPro

IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2

PFAM

PF00520
PF08016

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80W99

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

76856

UniGene

RefSeq

NP_084048

MGI ID

MGI Symbol

Catsper3

OMIM

CCDS

CCDS26555

HPRD

IMGT

EMBL

AK014942 AY263400 BC089518

GenPept

AAH89518 AAP21831 BAB29631