InnateDB Protein
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IDBP-261472.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Psmf1
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Protein Name
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proteasome (prosome, macropain) inhibitor subunit 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105495
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InnateDB Gene
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IDBG-209559 (Psmf1)
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Protein Structure
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Function |
Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
23 [view]
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Molecular Function |
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Biological Process |
GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:1901799
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negative regulation of proteasomal protein catabolic process
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Cellular Component |
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PDB ID |
MGI:1346072
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InterPro |
IPR013886
PI31 proteasome regulator
IPR021625
Fbxo7/PI31 domain
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PFAM |
PF08577
PF11566
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BHL8
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PhosphoSite |
PhosphoSite-Q8BHL8
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TrEMBL |
A2AU35
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UniProt Splice Variant |
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Entrez Gene |
228769
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UniGene |
Mm.420495
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RefSeq |
XP_006499369
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MGI ID |
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MGI Symbol |
Psmf1
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OMIM |
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CCDS |
CCDS16872
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HPRD |
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IMGT |
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EMBL |
AK031363
AK045891
AK053924
AK078867
BC131928
BC131930
CH466551
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GenPept |
AAI31929
AAI31931
BAC27368
BAC32522
BAC35596
BAC37430
EDL05932
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