Version 5.4
Mus musculus Protein: Clgn
Summary
InnateDB Protein IDBP-261550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clgn
Protein Name calmegin
Synonyms 4930459O04Rik; AI528775; Cln;
Species Mus musculus
Ensembl Protein ENSMUSP00000105457
InnateDB Gene IDBG-172004 (Clgn)
Protein Structure
UniProt Annotation
Function Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. {ECO:0000269PubMed:11784061, ECO:0000269PubMed:15151931, ECO:0000269PubMed:16870943, ECO:0000269PubMed:9177349}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:10495883}; Single-pass type I membrane protein {ECO:0000269PubMed:10495883}.
Disease Associations
Tissue Specificity Detected in testis (at protein level). Detected in testis. {ECO:0000269PubMed:11784061, ECO:0000269PubMed:8126001, ECO:0000269PubMed:8188695, ECO:0000269PubMed:9177349, ECO:0000269PubMed:9434179}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044183 protein binding involved in protein folding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006461 protein complex assembly
GO:0007126 meiotic nuclear division
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007339 binding of sperm to zona pellucida
GO:0030154 cell differentiation
Cellular Component
GO:0005635 nuclear envelope
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:107472
InterPro IPR001580 Calreticulin/calnexin
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR009033 Calreticulin/calnexin, P domain
PFAM PF00262
PRINTS PR00626
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P52194
PhosphoSite PhosphoSite-P52194
TrEMBL
UniProt Splice Variant
Entrez Gene 12745
UniGene Mm.416390
RefSeq NP_034034
MGI ID
MGI Symbol Clgn
OMIM
CCDS CCDS22452
HPRD
IMGT
EMBL AK019534 BC050767 D14117 D86323 U08373
GenPept AAA20599 AAH50767 BAA03180 BAA22591 BAB31782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca