Mus musculus Protein: Cdc14b | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-261682.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | Cdc14b | ||||||||||||
Protein Name | CDC14 cell division cycle 14 homolog B (S. cerevisiae) | ||||||||||||
Synonyms | |||||||||||||
Species | Mus musculus | ||||||||||||
Ensembl Protein | ENSMUSP00000105392 | ||||||||||||
InnateDB Gene | IDBG-161758 (Cdc14b) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1. {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | MGI:2441808 | ||||||||||||
InterPro |
IPR000242
Protein-tyrosine phosphatase, receptor/non-receptor type IPR000340 Dual specificity phosphatase, catalytic domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR020422 Dual specificity phosphatase, subgroup, catalytic domain IPR029021 Protein-tyrosine phosphatase-like |
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PFAM |
PF00102
PF00782 |
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PRINTS |
PR00700
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PIRSF | |||||||||||||
SMART |
SM00194
SM00404 SM00195 |
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q6PFY9 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 218294 | ||||||||||||
UniGene | Mm.415471 | ||||||||||||
RefSeq | XP_006517281 | ||||||||||||
MGI ID | |||||||||||||
MGI Symbol | Cdc14b | ||||||||||||
OMIM | |||||||||||||
CCDS | CCDS26598 | ||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | AK041155 BC049794 BC057357 | ||||||||||||
GenPept | AAH49794 AAH57357 BAC30842 | ||||||||||||