InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Txn2

Summary

InnateDB Protein

IDBP-261725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txn2

Protein Name

thioredoxin 2

Synonyms

2510006J11Rik; AI788873; Trx2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105370

InnateDB Gene

IDBG-158473 (Txn2)

Protein Structure

UniProt Annotation

Function

Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential (By similarity). Possesses a dithiol-reducing activity. {ECO:0000250, ECO:0000269PubMed:12529397}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015035	protein disulfide oxidoreductase activity
GO:0032403	protein complex binding

Biological Process

GO:0001666	response to hypoxia
GO:0006662	glycerol ether metabolic process
GO:0006979	response to oxidative stress
GO:0007584	response to nutrient
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0014070	response to organic cyclic compound
GO:0031669	cellular response to nutrient levels
GO:0042493	response to drug
GO:0045454	cell redox homeostasis
GO:0048678	response to axon injury
GO:0055114	oxidation-reduction process