Version 5.4
Mus musculus Protein: H2afv
Summary
InnateDB Protein IDBP-261752.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2afv
Protein Name H2A histone family, member V
Synonyms C530002L11Rik; H2a.z-2; H2av;
Species Mus musculus
Ensembl Protein ENSMUSP00000105359
InnateDB Gene IDBG-147812 (H2afv)
Protein Structure
UniProt Annotation
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006334 nucleosome assembly
GO:0008150 biological_process
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1924855
InterPro IPR002119 Histone H2A
IPR007125 Histone core
IPR009072 Histone-fold
PFAM PF00125
PRINTS PR00620
PIRSF
SMART SM00414
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3THW5
PhosphoSite PhosphoSite-Q3THW5
TrEMBL B2RVP5
UniProt Splice Variant
Entrez Gene 77605
UniGene
RefSeq NP_084214
MGI ID
MGI Symbol H2afv
OMIM
CCDS CCDS48750
HPRD
IMGT
EMBL AK021267 AK155105 AK168110 AL646020 BC147293 BC147294 BC147741 BC147751 CH466574
GenPept AAI47294 AAI47295 AAI47742 AAI47752 BAB32354 BAE33050 BAE40081 CAI26006 EDL40593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca