Version 5.4
| Mus musculus Protein: Rapgef5 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-261860.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Rapgef5 | ||||||||
| Protein Name | Rap guanine nucleotide exchange factor (GEF) 5 | ||||||||
| Synonyms | |||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000105313 | ||||||||
| InnateDB Gene | IDBG-178227 (Rapgef5) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Nucleus {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2444365 | ||||||||
| InterPro |
IPR000591
DEP domain IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal IPR001895 Guanine-nucleotide dissociation stimulator CDC25 IPR023578 Ras guanine nucleotide exchange factor, domain IPR029071 Ubiquitin-related domain |
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| PFAM |
PF00610
PF00618 PF00617 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00049
SM00229 SM00147 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8C0Q9 | ||||||||
| PhosphoSite | PhosphoSite-Q8C0Q9 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 217944 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_787126 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Rapgef5 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS36577 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK029995 AK030016 AK083591 AK122234 BC046627 | ||||||||
| GenPept | AAH46627 BAC26723 BAC26736 BAC38963 BAC65516 | ||||||||