InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vwc2

Summary

InnateDB Protein

IDBP-261878.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vwc2

Protein Name

von Willebrand factor C domain containing 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105303

InnateDB Gene

IDBG-150020 (Vwc2)

Protein Structure

UniProt Annotation

Function

BMP antagonist which may play a role in neural development. Promotes cell adhesion. {ECO:0000269PubMed:17400546, ECO:0000269PubMed:18757743}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Cell junction, synapse {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in the brain (at protein level). It is expressed in the neurons but not the glial cells. {ECO:0000269PubMed:17400546, ECO:0000269PubMed:18757743, ECO:0000269PubMed:22632720}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0010811	positive regulation of cell-substrate adhesion
GO:0030514	negative regulation of BMP signaling pathway
GO:0045666	positive regulation of neuron differentiation

Cellular Component

GO:0005604	basement membrane
GO:0005614	interstitial matrix
GO:0005615	extracellular space
GO:0030054	cell junction
GO:0031012	extracellular matrix
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0045202	synapse