InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tox3

Summary

InnateDB Protein

IDBP-262012.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tox3

Protein Name

TOX high mobility group box family member 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105250

InnateDB Gene

IDBG-179392 (Tox3)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0034056	estrogen response element binding
GO:0042803	protein homodimerization activity
GO:0051219	phosphoprotein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated