InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Chd9

Summary

InnateDB Protein

IDBP-262014.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chd9

Protein Name

chromodomain helicase DNA binding protein 9

Synonyms

1810014J18Rik; 9030205D12Rik; A330063D19Rik; AD013; mKIAA0308; PRIC320;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105243

InnateDB Gene

IDBG-179416 (Chd9)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA (By similarity). Associates with A/T- rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in osteoprogenitor cells during development and in mature bone (at protein level). {ECO:0000269PubMed:16419031}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016817	hydrolase activity, acting on acid anhydrides

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008150	biological_process
GO:0016568	chromatin modification

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1924001

InterPro

IPR000330 SNF2-related
IPR000953 Chromo domain/shadow
IPR001650 Helicase, C-terminal
IPR006576 BRK domain
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR016197 Chromo domain-like
IPR023780 Chromo domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF07533
PF04851
PF00270
PF00385

PRINTS

PIRSF

SMART

SM00298
SM00490
SM00592
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BYH8