InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cbx7

Summary

InnateDB Protein

IDBP-262018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cbx7

Protein Name

chromobox homolog 7

Synonyms

1600014J01Rik; AI851678; D15Ertd417e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105245

InnateDB Gene

IDBG-163180 (Cbx7)

Protein Structure

UniProt Annotation

Function

Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. {ECO:0000269PubMed:16537902, ECO:0000269PubMed:20541999}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14647293, ECO:0000269PubMed:20541999}. Note=Detected in faculative heterochromatin and on the inactivated X-chromosome in females.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003727	single-stranded RNA binding
GO:0005515	protein binding
GO:0035064	methylated histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0048733	sebaceous gland development