InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atf4

Summary

InnateDB Protein

IDBP-262036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atf4

Protein Name

activating transcription factor 4

Synonyms

Atf-4; C/ATF; CREB2; TAXREB67;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105234

InnateDB Gene

IDBG-163574 (Atf4)

Protein Structure

UniProt Annotation

Function

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. {ECO:0000269PubMed:15775988, ECO:0000269PubMed:21159964, ECO:0000269PubMed:21768648, ECO:0000269PubMed:22298775, ECO:0000269PubMed:22572884, ECO:0000269PubMed:23663782, ECO:0000269PubMed:8506317}.

Subcellular Localization

Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes. Colocalizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	23 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	66 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0034976	response to endoplasmic reticulum stress
GO:0043267	negative regulation of potassium ion transport
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress