InnateDB Protein
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IDBP-262080.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Sertad2
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Protein Name
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SERTA domain containing 2
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Synonyms
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AB041541; AU021878; Kiaa0127; mKIAA0127; SEI-2; Sei2; TRIP-Br2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105215
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InnateDB Gene
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IDBG-152872 (Sertad2)
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Protein Structure
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Function |
Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F- target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. {ECO:0000269PubMed:23291629}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in white and brown adipose tissue. {ECO:0000269PubMed:23291629}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1931026
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InterPro |
IPR009263
SERTA domain
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PFAM |
PF06031
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JJG5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q91VV6
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UniProt Splice Variant |
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Entrez Gene |
58172
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UniGene |
Mm.396846
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RefSeq |
NP_001033714
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MGI ID |
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MGI Symbol |
Sertad2
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OMIM |
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CCDS |
CCDS24458
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HPRD |
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IMGT |
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EMBL |
AB041541
AF366403
AK076787
AK129059
AK132846
AK132849
AK142018
AK146621
AK147674
BC008257
BC014726
CH466595
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GenPept |
AAH08257
AAH14726
AAK52832
BAA95026
BAC36480
BAC97869
BAE21389
BAE21392
BAE24915
BAE27310
BAE28066
EDL07837
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