InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STMN2

Summary

InnateDB Protein

IDBP-26224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STMN2

Protein Name

stathmin-like 2

Synonyms

SCG10; SCGN10;

Species

Homo sapiens

Ensembl Protein

ENSP00000220876

InnateDB Gene

IDBG-26222 (STMN2)

Protein Structure

UniProt Annotation

Function

Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon. Golgi apparatus. Endosome {ECO:0000250}. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. {ECO:0000250}.

Disease Associations

Tissue Specificity

Neuron specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.

Experimentally validated
Total	33 [view]
Protein-Protein	29 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0007026	negative regulation of microtubule depolymerization
GO:0010976	positive regulation of neuron projection development
GO:0010977	negative regulation of neuron projection development
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0031117	positive regulation of microtubule depolymerization
GO:1990090	cellular response to nerve growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm