Version 5.4
Mus musculus Protein: Lbp
Summary
InnateDB Protein IDBP-262281.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Lbp
Protein Name lipopolysaccharide binding protein
Synonyms Bpifd2; Ly88;
Species Mus musculus
Ensembl Protein ENSMUSP00000105117
InnateDB Gene IDBG-211482 (Lbp)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0008289 lipid binding
GO:0070891 lipoteichoic acid binding
Biological Process
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0006953 acute-phase response
GO:0015920 lipopolysaccharide transport
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032490 detection of molecule of bacterial origin
GO:0032496 response to lipopolysaccharide
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0043032 positive regulation of macrophage activation
GO:0044130 negative regulation of growth of symbiont in host
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0071223 cellular response to lipoteichoic acid
GO:0090023 positive regulation of neutrophil chemotaxis
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
Protein Structure and Domains
PDB ID MGI:1098776
InterPro IPR017942 Lipid-binding serum glycoprotein, N-terminal
IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
PFAM PF01273
PRINTS
PIRSF
SMART SM00328
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2AC65
UniProt Splice Variant
Entrez Gene 16803
UniGene Mm.416419
RefSeq
MGI ID
MGI Symbol Lbp
OMIM
CCDS
HPRD
IMGT
EMBL AL663063
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca